The Grap Polyclonal Antibody (CAB15391) is specifically designed for research involving Grap, a protein known for its role in cell signaling and cancer progression. This antibody, raised in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By binding to the Grap protein, this antibody enables detection and analysis in various cell types, making it an ideal tool for studies in cancer research and cell biology.Grap is a key player in signaling pathways that regulate cell growth, survival, and migration, making it a promising target for understanding cancer development and progression. Its involvement in pathways related to cell proliferation and survival underscores its potential significance in cancer biology.
Research on Grap has the potential to uncover new insights into the mechanisms driving cancer growth and metastasis, ultimately contributing to the development of novel therapeutic strategies targeting this protein.Overall, the Grap Polyclonal Antibody is a valuable tool for researchers exploring the role of Grap in cancer biology and signaling pathways. Its high reactivity and specificity make it an essential component for studies aiming to elucidate the function of Grap in various cellular processes, offering new avenues for advancing our understanding of cancer and potential therapeutic interventions.
Product Name:
GRAP Rabbit Polyclonal Antibody
SKU:
CAB15391
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 128-217 of human GRAP (NP_006604.1).
This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.
Purification Method:
Affinity purification
Gene ID:
10750
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GRAP Rabbit pAb (CAB15391) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
