The Granzyme K Polyclonal Antibody (CAB10219) is a valuable tool for researchers studying Granzyme K, a serine protease involved in immune responses, specifically targeting infected or cancerous cells for destruction. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the Granzyme K protein, researchers can accurately detect and analyze its expression in a variety of cell types, making it ideal for investigations in immunology and cancer research.
Granzyme K is a key player in the immune system's defense against pathogens and damaged cells, functioning in the cytotoxic response mediated by natural killer (NK) cells and cytotoxic T lymphocytes. Its role in inducing cell death in target cells highlights its potential as a therapeutic target for conditions like viral infections and cancer. Research into the mechanisms and functions of Granzyme K is vital for developing novel treatment strategies that exploit its cytotoxic capabilities for clinical applications.
Product Name:
GZMK Rabbit Polyclonal Antibody
SKU:
CAB10219
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 27-264 of human GZMK (NP_002095.1).
This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.
Purification Method:
Affinity purification
Gene ID:
3003
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GZMK antibody (CAB10219) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
