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Granzyme K monoclonal antibody (PE) (AGIM0005)

SKU:
AGIM0005
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
24C3
Conjugation:
PE
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:Granzyme K monoclonal antibody (PE)
Product Code:AGIM0005
Size:500 µL
Reactivity:Human
Clone:24C3
Applications:Flow Cytometry
Conjugate:PE
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P49863
Background:Granzymes are exogenous serine proteases that are stored in the cytotoxic granules of activated T cells and NK cells. Upon target cell contact, the contents of these granules are directionally exocytosed and, with the assistance of perforin, the granzymes enter the cytosol of the target cell. To date, five human granzymes (A, B, H, K, M) have been described at the molecular genetic level. Human granzyme K (GZMK) is a 28 kD serine protease whose gene is located on chromosome 5q11-12 close to the granzyme A-encoding gene. Like granzyme A, it has a trypsin-like specificity cleaving at the basic residues arginine and lysine. To which extent human granzyme K plays a role in the induction of apoptosis in the target cells remains to be evaluated. High mRNA levels of granzyme K are detected in activated T cells and NK cells but are absent in normal tissues that do not contain high numbers of these cells.
NCBI Summary:This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008]
UniProt Code:P49863
NCBI GenInfo Identifier:1708035
NCBI Gene ID:3003
NCBI Accession:P49863.1
UniProt Secondary Accession:P49863,B2R563,
UniProt Related Accession:P49863
Molecular Weight:
NCBI Full Name:Granzyme K
NCBI Synonym Full Names:granzyme K
NCBI Official Symbol:GZMK  
NCBI Official Synonym Symbols:TRYP2  
NCBI Protein Information:granzyme K
UniProt Protein Name:Granzyme K
UniProt Synonym Protein Names:Fragmentin-3; Granzyme-3; NK-tryptase-2; NK-Tryp-2
Protein Family:Granzyme
UniProt Gene Name:GZMK  

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