The Granzyme B Polyclonal Antibody (CAB2557) is a valuable tool for researchers studying the role of Granzyme B in immune responses and cell-mediated cytotoxicity. Granzyme B is a serine protease found in cytotoxic lymphocytes, and is involved in inducing apoptosis in target cells.This antibody, raised in rabbits, is highly specific to Granzyme B and has been validated for use in various applications, including Western blot and immunohistochemistry. Its high reactivity with human samples makes it ideal for studies in immunology, cancer research, and autoimmune diseases.
Granzyme B is a key player in the immune system's defense against infected or abnormal cells, making it a potential target for therapies aimed at boosting immune responses or treating cancers. By using the Granzyme B Polyclonal Antibody, researchers can better understand the mechanisms by which Granzyme B functions, leading to new insights and potential therapeutic strategies.
Product Name:
Granzyme B Rabbit Polyclonal Antibody
SKU:
CAB2557
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human Granzyme B (NP_004122.2).
This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis.
Purification Method:
Affinity purification
Gene ID:
3002
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Granzyme B Rabbit pAb (CAB2557) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
