The Granzyme A Polyclonal Antibody (CAB6231) is a valuable tool for researchers studying Granzyme A, a serine protease enzyme involved in immune responses, specifically in the induction of apoptosis in target cells. Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By targeting the Granzyme A protein, researchers can detect and analyze its presence in various cell types, making it a versatile tool for studies in immunology and cancer research.
Granzyme A plays a crucial role in the immune system by inducing cell death in infected or abnormal cells, helping to eliminate threats to the body. Its involvement in immune surveillance and regulation makes it an important target for research into diseases such as cancer, viral infections, and autoimmune disorders. By understanding the function and regulation of Granzyme A, researchers can explore potential therapeutic interventions that modulate immune responses in these conditions.
Product Name:
GZMA Rabbit Polyclonal Antibody
SKU:
CAB6231
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 29-262 of human GZMA (NP_006135.2).
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells.
Purification Method:
Affinity purification
Gene ID:
3001
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using GZMA Rabbit pAb (CAB6231) at 1:2500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
