The Granulins Polyclonal Antibody (CAB5773) is a crucial tool for researchers studying granulins, a family of growth factors involved in various cellular processes such as cell proliferation, migration, and inflammation. This antibody, generated in rabbits, exhibits high specificity and sensitivity when detecting granulin proteins in human samples, making it suitable for applications like Western blotting.Granulins are key players in tissue repair, wound healing, and neurodegenerative diseases, making them a promising target for research in biomedicine and neurology.
By using the Granulins Polyclonal Antibody, researchers can investigate the expression and function of granulins in different disease states, paving the way for potential therapeutic interventions and diagnostic tools. This antibody opens up new possibilities for understanding the roles of granulins in health and disease, making it an essential component in the study of cellular signaling pathways and disease mechanisms.
Product Name:
Granulin Rabbit Polyclonal Antibody
SKU:
CAB5773
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-310 of human Granulin (NP_002078.1).
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
Purification Method:
Affinity purification
Gene ID:
2896
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Granulin Rabbit pAb (CAB5773) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 5s.
