Granulin Rabbit Monoclonal Antibody (CAB5124)
- SKU:
- CAB5124
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | Granulin Rabbit Monoclonal Antibody |
SKU: | CAB5124 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human Granulin (NP_002078.1). |
Sequence: | CPDG QFCP VACC LDPG GASY SCCR PLLD KWPT TLSR HLGG PCQV DAHC SAGH SCIF TVSG TSSC CPFP EAVA CGDG HHCC PRGF HCSA DGRS CFQR SGNN SVGA IQCP DSQF ECPD FSTC CVMV DGSW GCCP MPQA SCCE DRVH CCPH GAFC DLVH TRCI TPTG THPL AKKL PAQR TNRA V |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | GEP; GP88; PEPI; PGRN; CLN11; PCDGF; Granulin |
Positive Sample: | A-431,HepG2,293T |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted |
Calculated MW: | 44kDa/46kDa/63kDa |
Observed MW: | 75kDa |
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
Purification Method: | Affinity purification |
Gene ID: | 2896 |
Clone Number: | ARC51129 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |