Granulin Monoclonal Antibody (CAB23230)
- SKU:
- CAB23230
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | Granulin Monoclonal Antibody |
SKU: | CAB23230 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 494-593 of human Granulin (NP_002078.1). |
Sequence: | SCEK EVVS AQPA TFLA RSPH VGVK DVEC GEGH FCHD NQTC CRDN RQGW ACCP YRQG VCCA DRRH CCPA GFRC AARG TKCL RREA PRWD APLR DPAL RQLL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 |
Synonyms: | GEP; GP88; PEPI; PGRN; CLN11; PCDGF; Granulin |
Positive Sample: | HeLa,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted, Lysosome. |
Calculated MW: | 64kDa |
Observed MW: | 75-88kDa |
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
Purification Method: | Affinity purification |
Gene ID: | 2896 |
Clone Number: | ARC59451 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |