The Granulin Monoclonal Antibody (CAB23230) is a specialized tool for research involving granulin, a protein associated with various cellular processes, including cell growth and inflammation. This monoclonal antibody, created using cutting-edge technology, specifically targets granulin and is highly reactive with human samples.Granulin is known to play a key role in cancer development and progression, making it a significant target for studies in oncology research. By utilizing this antibody in Western blot applications, researchers can effectively detect and analyze granulin levels in different cell types, providing valuable insights into its function and potential implications in cancer biology.
Furthermore, granulin has been linked to neurodegenerative diseases and inflammatory conditions, highlighting its diverse roles in various physiological and pathological processes. The Granulin Monoclonal Antibody offers a powerful tool for investigating the complex mechanisms involving granulin, paving the way for advancements in understanding and potentially targeting this protein in the treatment of related diseases.
Product Name:
Granulin Monoclonal Antibody
SKU:
CAB23230
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 494-593 of human Granulin (NP_002078.1).
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
Purification Method:
Affinity purification
Gene ID:
2896
Clone Number:
ARC59451
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of HeLa, using Granulin Rabbit mAb (CAB23230) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
