The GRAMD4 Polyclonal Antibody (PAC048662) is a valuable tool for researchers studying the GRAMD4 protein, a key player in lipid metabolism and membrane trafficking. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting GRAMD4 in human samples, making it an essential component for Western blot applications.GRAMD4, a member of the GRAM domain-containing protein family, is involved in the regulation of lipid transfer between organelles, contributing to proper cellular function and structure. Its role in membrane trafficking processes and lipid homeostasis implicates GRAMD4 in various cellular pathways, making it a promising target for investigation in areas such as lipid metabolism, cell biology, and neurodegenerative diseases.
By utilizing the GRAMD4 Polyclonal Antibody, researchers can explore the functions and mechanisms of GRAMD4 in different cellular contexts, aiding in the development of novel therapies and potential interventions targeting lipid metabolism-related disorders. With its reliability and specificity, this antibody is essential for advancing research in the fields of lipid biology and cellular physiology.
Western Blot. Positive WB detected in: Mouse brain tissue. All lanes: GRAMD4 antibody at 3.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 67, 11 kDa. Observed band size: 67 kDa..
Western Blot. Positive WB detected in: MCF-7 whole cell lysate. All lanes: GRAMD4 antibody at 5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 67, 11 kDa. Observed band size: 67 kDa.
Immunohistochemistry of paraffin-embedded human breast cancer using PACO48662 at dilution of 1:100.
Background:
Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53.
Synonyms:
GRAM domain-containing protein 4 (Death-inducing protein), GRAMD4, DIP KIAA0767
UniProt Protein Function:
DIP: Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Apoptosis; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 22q13.31
UniProt Protein Details:
NCBI Summary:
GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis (Stanelle et al., 2005 [PubMed 15565177]).[supplied by OMIM, Jan 2011]
