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GR (Phospho-Ser211) Transcription Factor Activity Assay

SKU:
TFAB00033
Product Type:
ELISA Kit
ELISA Type:
Transcription Factor Assay
Analytes:
GR (Phospho-Ser211)
Reactivity:
Human
Mouse
Rat
€599
Frequently bought together:

Description

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GR (Phospho-Ser211)Transcription Factor Activity Assay

The GR (phospho Ser211) Transcription Factor Activity Assay is a highly sensitive and specific kit designed for the accurate detection of phosphorylated Ser211 levels of the GR transcription factor in cell lysates. This assay provides reliable and reproducible results, making it ideal for studying the activity of the GR transcription factor in various research applications.The GR transcription factor plays a crucial role in regulating gene expression and mediating cellular responses to stress and inflammation. Phosphorylation of Ser211 is known to enhance the transcriptional activity of GR, leading to the expression of genes involved in immune and inflammatory responses.

Understanding the activity of the GR transcription factor can provide valuable insights into the processes underlying various diseases, including cancer, autoimmune disorders, and metabolic diseases.With its high sensitivity and specificity, the GR (phospho Ser211) Transcription Factor Activity Assay is a valuable tool for researchers studying the role of the GR transcription factor in health and disease. Its ease of use and robust performance make it an essential addition to any laboratory conducting research on transcriptional regulation and cellular signaling pathways.

Product Name:GR (Phospho-Ser211) Transcription Factor Activity Assay
Product Code:TFAB00033
Target:GR (Phospho-Ser211)
Synonyms:Nuclear receptor subfamily 3 group C member 1
Reactivity:Human, Mouse, Rat
Sample Types:Nuclear or cell lysates

The Assay Genie GR (Phospho-Ser211) transcription factor activity assay allows for detection and qualitative analysis of GR (Phospho-Ser211) active transcription factors in eukaryotic nuclear or cell lysates.

Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.

Assay Time:4.5 hours
Detection Method:Colorimetric 450 nm
Size:12 x 8-Well Microstrips
Storage:4°C for 6 months
UniProt Protein Function:GR: transcription factor of the nuclear receptor family. Receptor for glucocorticoids (GC). Binds to glucocorticoid response elements (GRE) and modulates other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Three alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Mitochondrial; DNA-binding; Transcription factor; Nuclear receptor

Chromosomal Location of Human Ortholog: 5q31.3

Cellular Component: cytoplasm; cytosol; membrane; mitochondrial matrix; nucleoplasm; nucleus

Molecular Function:glucocorticoid receptor activity; protein binding; protein dimerization activity; steroid binding; transcription factor activity; zinc ion binding

Biological Process: adrenal gland development; chromatin modification; gene expression; glucocorticoid mediated signaling; glucocorticoid metabolic process; glucocorticoid receptor signaling pathway; maternal behavior; positive regulation of neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; regulation of glucocorticoid biosynthetic process; regulation of gluconeogenesis; regulation of transcription, DNA-dependent; signal transduction; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent

Disease: Glucocorticoid Resistance, Generalized

NCBI Summary:This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
UniProt Code:P04150
NCBI GenInfo Identifier:121069
NCBI Gene ID:2908
NCBI Accession:P04150.1
UniProt Secondary Accession:P04150,P04151, Q53EP5, Q6N0A4, A0ZXF9, B0LPG8, D3DQF4
UniProt Related Accession:P04150
Molecular Weight:82,904 Da
NCBI Full Name:Glucocorticoid receptor
NCBI Synonym Full Names:nuclear receptor subfamily 3 group C member 1
NCBI Official Symbol:NR3C1  
NCBI Official Synonym Symbols:GR; GCR; GRL; GCCR; GCRST  
NCBI Protein Information:glucocorticoid receptor
UniProt Protein Name:Glucocorticoid receptor
UniProt Synonym Protein Names:Nuclear receptor subfamily 3 group C member 1
Protein Family:Glucocorticoid receptor
UniProt Gene Name:NR3C1  
UniProt Entry Name:GCR_HUMAN
AntibodiesELISA Kits
Anti-NR3C1 Antibody (CAB13667)Human GR alpha (Glucocorticoid Receptor Alpha) CLIA Kit (HUES01082)
Anti-Glucocorticoid Receptor Antibody (CAB19583)GR (Phospho-Ser211) Colorimetric Cell-Based ELISA Kit
Anti-NR3C1 Antibody (CAB2164)GR (Phospho-Ser226) Colorimetric Cell-Based ELISA Kit
Anti-Phospho-NR3C1-S211 pAb Antibody (CABP0759)GR Transcription Factor Activity Assay
NR3C1 Antibody (PACO00094)

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