The GPVI/GP6 Polyclonal Antibody is an essential tool for researchers studying GPVI and GP6, two key receptors involved in platelet activation and thrombus formation. This antibody, produced through immunization of rabbits, demonstrates high specificity and sensitivity when used in Western blotting and immunohistochemistry applications with human samples.GPVI and GP6 are crucial for mediating platelet adhesion and aggregation in response to vascular injury, playing a pivotal role in hemostasis and thrombosis. Dysregulation of these receptors has been linked to various cardiovascular diseases, making them important targets for therapeutic development and understanding disease mechanisms.
With its ability to specifically bind to GPVI and GP6 proteins, this polyclonal antibody enables precise detection and analysis in a variety of cell types, providing valuable insights into platelet function, thrombosis, and related diseases. Researchers in the fields of cardiovascular biology and hematology will benefit from using this antibody to advance their studies and contribute to the development of new treatment strategies.
Product Name:
GPVI/GP6 Polyclonal Antibody
SKU:
CAB24524
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 24-265 of mouse GPVI/GP6 (NP_001156486.1).
Enables collagen binding activity and collagen receptor activity. Involved in vasculature development. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway. Is integral component of plasma membrane. Is expressed in bone marrow; femur; liver; and spleen. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 11. Orthologous to human GP6 (glycoprotein VI platelet).
Purification Method:
Affinity purification
Gene ID:
243816
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of Human plasma, using GPVI/GP6 Rabbit pAb (CAB24524) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
