GPS2 Antibody (PACO53666)
- SKU:
- PACO53666
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
GPS2 Antibody (PACO53666)
The GPS2 Antibody (PAC053666) is a polyclonal antibody designed for research involving GPS2, a protein known for its role in transcriptional regulation and nuclear receptor signaling. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. It specifically binds to the GPS2 protein, allowing for the detection and analysis of GPS2 expression in various cell types.GPS2 is a key component of transcriptional regulatory complexes and has been implicated in the regulation of metabolic pathways and inflammatory responses.
Its involvement in these processes makes it a valuable target for research in areas such as metabolic disorders, inflammation, and cancer. By studying the function of GPS2, researchers can gain insights into its role in various physiological and pathological conditions, potentially leading to the development of novel therapeutic strategies.
| Antibody Name: | GPS2 Antibody (PACO53666) |
| Antibody SKU: | PACO53666 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human G protein pathway suppressor 2 protein (1-327AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescent analysis of Hela cells using PACO53666 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. |
| Synonyms: | G protein pathway suppressor 2 (GPS-2), GPS2 |
| UniProt Protein Function: | GPS2: Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Inhibitor; G protein regulator, misc.; Cell cycle regulationChromosomal Location of Human Ortholog: 17p13Cellular Component: nucleoplasm; transcriptional repressor complexMolecular Function: protein binding; transcription corepressor activity; GTPase inhibitor activityBiological Process: negative regulation of JNK cascade; establishment and/or maintenance of chromatin architecture; JNK cascade; negative regulation of transcription from RNA polymerase II promoter; cell cycle; inactivation of MAPK activity |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13227 |
| NCBI GenInfo Identifier: | 6226623 |
| NCBI Gene ID: | 2874 |
| NCBI Accession: | Q13227.3 |
| UniProt Secondary Accession: | Q13227,Q6FHM8, B4DXA1 |
| UniProt Related Accession: | Q13227 |
| Molecular Weight: | 37kDa |
| NCBI Full Name: | G protein pathway suppressor 2 |
| NCBI Synonym Full Names: | G protein pathway suppressor 2 |
| NCBI Official Symbol: | GPS2Â Â |
| NCBI Official Synonym Symbols: | AMF-1Â Â |
| NCBI Protein Information: | G protein pathway suppressor 2; GPS-2 |
| UniProt Protein Name: | G protein pathway suppressor 2 |
| UniProt Synonym Protein Names: | |
| Protein Family: | G protein pathway suppressor |
| UniProt Gene Name: | GPS2Â Â |
| UniProt Entry Name: | GPS2_HUMAN |
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