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GPS2 Antibody (PACO09572)

SKU:
PACO09572
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
Frequently bought together:

Description

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GPS2 Antibody (PACO09572)

The GPS2 Polyclonal Antibody (PACO09572) is a valuable tool for researchers studying the GPS2 protein, a critical component in gene regulation and nuclear receptor signaling pathways. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot analysis.GPS2, or G-Protein Pathway Suppressor 2, is known for its role in modulating transcriptional processes and inflammatory responses.

Dysfunction of GPS2 has been linked to various diseases, including cancer and metabolic disorders, highlighting its potential as a therapeutic target. By using the GPS2 Polyclonal Antibody, researchers can investigate the function and regulation of GPS2 in different cellular environments, providing valuable insights into disease mechanisms and potential treatment strategies.

Antibody Name:GPS2 Antibody (PACO09572)
Antibody SKU:PACO09572
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human GPS2
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:G protein pathway suppressor 2;GPS2;AMF-1;MGC104294;MGC119287;MGC119288;MGC119289 ;
UniProt Protein Function:GPS2: Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Inhibitor; G protein regulator, misc.; Cell cycle regulationChromosomal Location of Human Ortholog: 17p13Cellular Component: nucleoplasm; transcriptional repressor complexMolecular Function: protein binding; transcription corepressor activity; GTPase inhibitor activityBiological Process: negative regulation of JNK cascade; establishment and/or maintenance of chromatin architecture; JNK cascade; negative regulation of transcription from RNA polymerase II promoter; cell cycle; inactivation of MAPK activity
UniProt Protein Details:
NCBI Summary:This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]
UniProt Code:Q13227
NCBI GenInfo Identifier:6226623
NCBI Gene ID:2874
NCBI Accession:Q13227.3
UniProt Secondary Accession:Q13227,Q6FHM8, B4DXA1
UniProt Related Accession:Q13227
Molecular Weight:37kDa
NCBI Full Name:G protein pathway suppressor 2
NCBI Synonym Full Names:G protein pathway suppressor 2
NCBI Official Symbol:GPS2  
NCBI Official Synonym Symbols:AMF-1  
NCBI Protein Information:G protein pathway suppressor 2; GPS-2
UniProt Protein Name:G protein pathway suppressor 2
UniProt Synonym Protein Names:
Protein Family:G protein pathway suppressor
UniProt Gene Name:GPS2  
UniProt Entry Name:GPS2_HUMAN

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