The GPS2 Polyclonal Antibody (PAC02789) is a valuable tool for researchers studying GPS2, a key protein involved in transcriptional regulation and cellular processes. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in various applications, including Western blotting and immunofluorescence.GPS2, a component of the nuclear receptor co-repressor complex, is essential for controlling gene expression and modulating various signaling pathways. Its role in regulating transcriptional activity makes it a crucial target for investigation in fields such as cell biology, epigenetics, and cancer research.
By detecting and analyzing GPS2 protein levels, researchers can gain insights into its functions and potential therapeutic implications.In summary, the GPS2 Polyclonal Antibody (PAC02789) is an essential tool for studying the functions and mechanisms of GPS2 in various cellular processes and diseases. Its high reactivity and specificity make it a reliable choice for researchers seeking to unravel the intricate roles of GPS2 in transcriptional regulation and beyond.
Antibody Name:
GPS2 Antibody
Antibody SKU:
PACO02789
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the N-terminal region of human GPS2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
GPS2; G protein pathway suppressor 2; GPS-2
UniProt Protein Function:
GPS2: Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Inhibitor; G protein regulator, misc.; Cell cycle regulationChromosomal Location of Human Ortholog: 17p13Cellular Component: nucleoplasm; transcriptional repressor complexMolecular Function: protein binding; transcription corepressor activity; GTPase inhibitor activityBiological Process: negative regulation of JNK cascade; establishment and/or maintenance of chromatin architecture; JNK cascade; negative regulation of transcription from RNA polymerase II promoter; cell cycle; inactivation of MAPK activity
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]
