The GPR84 Polyclonal Antibody (PAC040638) is a valuable tool for researchers studying GPR84, a G protein-coupled receptor involved in immune response regulation and inflammation. This antibody, generated in rabbits, demonstrates high specificity for human samples and has been validated for use in Western blotting applications. By binding to the GPR84 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it ideal for investigations in immunology and inflammatory diseases.
GPR84, also known as a pro-inflammatory receptor, has been implicated in various inflammatory conditions and is a potential therapeutic target for diseases such as inflammatory bowel disease and rheumatoid arthritis. By understanding the role of GPR84 in immune regulation, researchers can develop novel approaches for treating these debilitating conditions. This GPR84 antibody offers a reliable tool for exploring the functions of GPR84 and its implications in both basic research and drug development efforts.
Antibody Name:
GPR84 Antibody (PACO40638)
Antibody SKU:
PACO40638
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human G-protein coupled receptor 84 protein (202-320AA)
Immunofluorescent analysis of Hela cells using PACO40638 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Receptor for medium-chain free fatty acid, (FFA) with carbon chain lengths of C9 to C14. Capric acid, (C10:0), undecanoic acid, (C11:0) and lauric acid, (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid, is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid, metabolism to regulation of the immune system.
GPR84: Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, multi-pass; Motility/polarity/chemotaxis; GPCR, family 1; Receptor, GPCR; Membrane protein, integralChromosomal Location of Human Ortholog: 12q13.13Cellular Component: plasma membrane; integral to membrane; receptor complexMolecular Function: G-protein coupled receptor activityBiological Process: G-protein coupled receptor protein signaling pathway
