The GPR65 Polyclonal Antibody (PACO19740) is a valuable tool for researchers studying G Protein-Coupled Receptor 65 (GPR65), a cell surface receptor involved in immune regulation and inflammation. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the GPR65 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for studies in immunology and cancer research.GPR65, also known as TDAG8, plays a crucial role in immune cell function and regulation of immune responses.
Its involvement in inflammatory processes and immune cell activation positions it as a promising target for research on various diseases, including cancer, autoimmune disorders, and inflammatory conditions. The exploration of GPR65 activity is key to developing novel therapies that modulate immune function and combat disease progression.Overall, the GPR65 Polyclonal Antibody offers researchers a reliable tool for investigating the function and significance of GPR65 in immune regulation and disease pathology, paving the way for the development of innovative treatments and interventions in the field of immunology.
Antibody Name:
GPR65 Antibody (PACO19740)
Antibody SKU:
PACO19740
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human GPR65
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19740(GPR65 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO19740(GPR65 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
TDAG8 (for T-cell death-associated gene 8) is a seven transmembrane G protein-coupled receptor (GPCR) that was originally identified from a human thyroid cDNA library and subsequently shown to be expressed predominantly in thymus, lymph nodes, peripheral blood leukocytes and spleen. TDAG8, which is alternatively designated GPCR25, is grouped collectively with other GPCRs that are induced during T cell receptor engagement-mediated apoptosis and T cell activation, which also include G2A (for G2 accumulation) and P2Y2 (for P2 nucleotide) receptor.
Synonyms:
G protein-coupled receptor 65
UniProt Protein Function:
GPR65: Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. May have a role in activation- induced cell death or differentiation of T-cells. Belongs to the G-protein coupled receptor 1 family.Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 14q31-q32.1Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: G-protein coupled receptor activityBiological Process: actin cytoskeleton reorganization; G-protein coupled receptor protein signaling pathway; immune response; multicellular organismal development; positive regulation of cAMP biosynthetic process; positive regulation of stress fiber formation; response to acidity
