The GPR65 Polyclonal Antibody (PACO19739) is a valuable tool for researchers studying GPR65, a G protein-coupled receptor involved in immune responses and inflammation. This antibody is raised in rabbits and has high reactivity with human samples, making it suitable for use in Western blot applications. By binding specifically to the GPR65 protein, this antibody enables accurate detection and analysis in a variety of cell types.GPR65, also known as TDAG8, is a key player in regulating immune responses and inflammatory processes, making it a promising target for research in immunology and cancer.
Understanding the role of GPR65 can provide insights into diseases such as autoimmune disorders, chronic inflammation, and cancer, paving the way for the development of therapeutic interventions that target this receptor.Overall, the GPR65 Polyclonal Antibody (PACO19739) is a valuable tool for researchers looking to study the function and regulation of GPR65 in various physiological and pathological conditions. Its high specificity and reactivity make it an ideal choice for experiments aimed at uncovering the role of GPR65 in immune modulation and disease development.
Antibody Name:
GPR65 Antibody (PACO19739)
Antibody SKU:
PACO19739
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human GPR65
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19739(GPR65 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
TDAG8 (for T-cell death-associated gene 8) is a seven transmembrane G protein-coupled receptor (GPCR) that was originally identified from a human thyroid cDNA library and subsequently shown to be expressed predominantly in thymus, lymph nodes, peripheral blood leukocytes and spleen. TDAG8, which is alternatively designated GPCR25, is grouped collectively with other GPCRs that are induced during T cell receptor engagement-mediated apoptosis and T cell activation, which also include G2A (for G2 accumulation) and P2Y2 (for P2 nucleotide) receptor.
Synonyms:
G protein-coupled receptor 65
UniProt Protein Function:
GPR65: Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. May have a role in activation- induced cell death or differentiation of T-cells. Belongs to the G-protein coupled receptor 1 family.Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 14q31-q32.1Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: G-protein coupled receptor activityBiological Process: actin cytoskeleton reorganization; G-protein coupled receptor protein signaling pathway; immune response; multicellular organismal development; positive regulation of cAMP biosynthetic process; positive regulation of stress fiber formation; response to acidity
