UniProt Protein Function: | GPR39: Zn(2+) acts as a agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integralChromosomal Location of Human Ortholog: 2q21-q22Cellular Component: integral to plasma membrane; plasma membrane |
UniProt Protein Details: | |
NCBI Summary: | This gene is a member of the ghrelin receptor family and encodes a rhodopsin-type G-protein-coupled receptor (GPCR). The encoded protein is involved in zinc-dependent signaling in epithelial tissue in intestines, prostate and salivary glands. The protein may also be involved in the pathophysiology of depression. [provided by RefSeq, Jun 2016] |
UniProt Code: | O43194 |
NCBI GenInfo Identifier: | 3913748 |
NCBI Gene ID: | 2863 |
NCBI Accession: | O43194.1 |
UniProt Secondary Accession: | O43194,Q08AS2, Q53R01, B2RC12, B6V9G4 |
UniProt Related Accession: | O43194 |
Molecular Weight: | 51,329 Da |
NCBI Full Name: | G-protein coupled receptor 39 |
NCBI Synonym Full Names: | G protein-coupled receptor 39 |
NCBI Official Symbol: | GPR39Â Â |
NCBI Official Synonym Symbols: | |
NCBI Protein Information: | G-protein coupled receptor 39 |
UniProt Protein Name: | G-protein coupled receptor 39 |
UniProt Synonym Protein Names: | |
Protein Family: | G-protein coupled receptor |
UniProt Gene Name: | GPR39Â Â |
UniProt Entry Name: | GPR39_HUMAN |