The GPR39 Antibody (PAC019738) is a polyclonal antibody designed for research involving GPR39, a G protein-coupled receptor known to play a role in various physiological processes. This antibody, generated in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications.GPR39 is involved in regulating important cellular functions such as metabolism, growth, and energy homeostasis. Its diverse roles in different tissues make it a promising target for studies in metabolic diseases, neurobiology, and gastrointestinal health.
By detecting and analyzing the GPR39 protein in various cell types, this antibody is ideal for researchers in these fields looking to elucidate the mechanisms underlying GPR39 signaling pathways.Understanding the function of GPR39 is essential for developing potential therapeutic interventions for metabolic disorders, neurological diseases, and gastrointestinal conditions. This antibody provides a valuable tool for researchers seeking to further investigate the role of GPR39 in health and disease.
Antibody Name:
GPR39 Antibody (PACO19738)
Antibody SKU:
PACO19738
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human GPR39
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A431 cells, K562 cells, Primary antibody: PACO19738(GPR39 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes.
Background:
G-protein coupled receptor 39 is a protein that in humans is encoded by the GPR39 gene. The predicted 453-amino acid, GPR39 protein contains the 7 transmembrane domains characteristic of GPCRs. By sequence comparison with other GPCRs, the protein sequence of GPR39 is 27% and 32% identical to that of GSHR and neurotensin receptor-1, respectively. Northern blot analysis revealed that GPR39 is expressed widely as a 1.8- to 2-kb mRNA. A 3-kb transcript is present on Northern blots of some tissues, either in addition to the smaller mRNA or as the only hybridizing band.
Synonyms:
G protein-coupled receptor 39
UniProt Protein Function:
GPR39: Zn(2+) acts as a agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integralChromosomal Location of Human Ortholog: 2q21-q22Cellular Component: integral to plasma membrane; plasma membrane
UniProt Protein Details:
NCBI Summary:
This gene is a member of the ghrelin receptor family and encodes a rhodopsin-type G-protein-coupled receptor (GPCR). The encoded protein is involved in zinc-dependent signaling in epithelial tissue in intestines, prostate and salivary glands. The protein may also be involved in the pathophysiology of depression. [provided by RefSeq, Jun 2016]
