UniProt Protein Function: | GPR31: High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B. Belongs to the G-protein coupled receptor 1 family.Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCRChromosomal Location of Human Ortholog: 6q27Cellular Component: integral to plasma membrane; plasma membrane |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | O00270 |
NCBI GenInfo Identifier: | 153792268 |
NCBI Gene ID: | 2853 |
NCBI Accession: | NP_005290.2 |
UniProt Secondary Accession: | O00270,Q4VBL3, Q9NQ20, B0M0K2 |
UniProt Related Accession: | O00270 |
Molecular Weight: | 35kDa |
NCBI Full Name: | 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor |
NCBI Synonym Full Names: | G protein-coupled receptor 31 |
NCBI Official Symbol: | GPR31Â Â |
NCBI Official Synonym Symbols: | HETER; HETER1; 12-HETERÂ Â |
NCBI Protein Information: | 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor |
UniProt Protein Name: | 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor |
UniProt Synonym Protein Names: | G-protein coupled receptor 31 |
Protein Family: | 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor |
UniProt Gene Name: | GPR31Â Â |
UniProt Entry Name: | GPR31_HUMAN |