The GPR31 Polyclonal Antibody (PAC003943) is a valuable tool for researchers studying GPR31, a G protein-coupled receptor involved in various biological processes, including inflammation and immune response. This antibody, produced in rabbits, shows high reactivity with human samples and is suitable for use in Western blot applications. By binding to the GPR31 protein, this antibody allows for accurate detection and analysis in different cell types, making it an essential asset for investigations in immunology, inflammation, and cancer research.GPR31, also known as orphan G protein-coupled receptor 31, plays a critical role in modulating immune responses and inflammatory processes.
Its involvement in these pathways suggests its potential as a therapeutic target for diseases characterized by dysregulated immune responses, such as autoimmune disorders and chronic inflammatory conditions. By studying the function of GPR31, researchers aim to uncover new insights that could lead to the development of novel treatments aimed at modulating immune function and inflammation in various disease contexts.
Antibody Name:
GPR31 Antibody
Antibody SKU:
PACO03943
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human GPR31.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
GPR31: High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B. Belongs to the G-protein coupled receptor 1 family.Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCRChromosomal Location of Human Ortholog: 6q27Cellular Component: integral to plasma membrane; plasma membrane
