GPR179 Antibody (PACO47966)
- SKU:
- PACO47966
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
GPR179 Antibody (PACO47966)
The GPR179 Polyclonal Antibody (PAC047966) is a valuable tool for research involving GPR179, a G protein-coupled receptor involved in visual signal transduction in the retina. This antibody is raised in rabbits and has high reactivity with human samples, making it ideal for use in Western blot applications. It specifically binds to the GPR179 protein, allowing for detection and analysis in various experimental settings.
This antibody is essential for studies in vision biology, neuroscience, and ophthalmology, providing valuable insights into the role of GPR179 in visual function and potential implications for retinal diseases and disorders. Understanding the function of GPR179 is crucial for advancing our knowledge of vision processes and developing targeted therapies for retinal conditions.
| Antibody Name: | GPR179 Antibody (PACO47966) |
| Antibody SKU: | PACO47966 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Probable G-protein coupled receptor 179 protein (1440-1671AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human liver tissue using PACO47966 at dilution of 1:100. |
 | Immunofluorescent analysis of Hela cells using PACO47966 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Orphan receptor, involved in vision. Required for signal transduction through retinal depolarizing bipolar cells. |
| Synonyms: | Probable G-protein coupled receptor 179 (Probable G-protein coupled receptor 158-like 1) (GPR158-like), GPR179, GPR158L GPR158L1 |
| UniProt Protein Function: | GPR179: Orphan receptor, involved in vision. Required for signal transduction through retinal depolarizing bipolar cells. Defects in GPR179 are the cause of congenital stationary night blindness type 1E (CSNB1E). An autosomal recessive, non-progressive retinal disorder characterized by impaired night vision, absence of the electroretinogram (ERG) b- wave, and variable degrees of involvement of other visual functions. Affected individuals have an ERG waveform that lacks the b-wave because of failure to transmit the photoreceptor signal through the retinal depolarizing bipolar cells. Belongs to the G-protein coupled receptor 3 family.Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCRChromosomal Location of Human Ortholog: 17q12Cellular Component: integral component of membrane; plasma membraneMolecular Function: G-protein coupled receptor activityBiological Process: G-protein coupled receptor signaling pathway; visual perceptionDisease: Night Blindness, Congenital Stationary, Type 1e |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the glutamate receptor subfamily of G protein-coupled receptors. The encoded protein has an EGF-like calcium binding domain and a seven transmembrane domain in the N-terminal region of the protein. Mutations in this gene are associated with congenital stationary night blindness type 1E. [provided by RefSeq, Apr 2012] |
| UniProt Code: | Q6PRD1 |
| NCBI GenInfo Identifier: | 629266054 |
| NCBI Gene ID: | 440435 |
| NCBI Accession: | NP_001004334.3 |
| UniProt Secondary Accession: | Q6PRD1 |
| UniProt Related Accession: | Q6PRD1 |
| Molecular Weight: | |
| NCBI Full Name: | probable G-protein coupled receptor 179 |
| NCBI Synonym Full Names: | G protein-coupled receptor 179 |
| NCBI Official Symbol: | GPR179Â Â |
| NCBI Official Synonym Symbols: | CSNB1E; GPR158L; GPR158L1Â Â |
| NCBI Protein Information: | probable G-protein coupled receptor 179 |
| UniProt Protein Name: | Probable G-protein coupled receptor 179 |
| UniProt Synonym Protein Names: | Probable G-protein coupled receptor 158-like 1; GPR158-like |
| Protein Family: | |
| UniProt Gene Name: | GPR179Â Â |
| UniProt Entry Name: |
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