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GPR161 Antibody (PACO31804)

SKU:
PACO31804
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • GPR161 Antibody PACO31804
  • GPR161 Antibody PACO31804
€339

Description

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GPR161 Antibody (PACO31804)

The GPR161 Polyclonal Antibody (PAC031804) offered by AssayGenie is a valuable tool for researchers studying GPR161, a G protein-coupled receptor involved in various cellular processes. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting GPR161 in human samples, making it an ideal choice for use in Western blot applications.GPR161 is known to play a role in signaling pathways that regulate cell growth, differentiation, and development. By targeting GPR161, researchers can gain insights into its function and potential implications in disease states such as cancer and neurological disorders.

The ability to accurately detect and quantify GPR161 expression in different cell types makes this polyclonal antibody a valuable asset for studies focused on understanding the biological mechanisms involving GPR161.With its proven performance in Western blot applications, the GPR161 Polyclonal Antibody from AssayGenie is a reliable tool for researchers looking to explore the role of GPR161 in various physiological and pathological processes.

Antibody Name:GPR161 Antibody (PACO31804)
Antibody SKU:PACO31804
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IF
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:1000-1:5000, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human G-protein coupled receptor 161 protein (1-28AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot
All lanes: GPR161 antibody at 2µg/ml + EC109 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/15000 dilution
Predicted band size: 59, 46, 44, 50, 47, 61 kDa
Observed band size: 30 kDa
.
Product ImageImmunofluorescent analysis of Hela cells using PACO31804 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).
Synonyms:G-protein coupled receptor 161 (G-protein coupled receptor RE2), GPR161
UniProt Protein Function:GPR161: Orphan receptor. Plays a role in neurulation and lens development. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCRChromosomal Location of Human Ortholog: 1q24.2Cellular Component: cilium; recycling endosomeMolecular Function: G-protein coupled receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; positive regulation of cAMP biosynthetic process
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, this gene is a potential drug target for triple-negative breast cancer. [provided by RefSeq, Mar 2017]
UniProt Code:Q8N6U8
NCBI GenInfo Identifier:390190202
NCBI Gene ID:23432
NCBI Accession:NP_001254538.1
UniProt Secondary Accession:Q8N6U8,O75963, Q5TGK0, Q5TGK1, Q5TGK2, B3KV34, B7Z5D7 B7Z5E8, B7Z5Z6, F5GXD6
UniProt Related Accession:Q8N6U8
Molecular Weight:30.4kD
NCBI Full Name:G-protein coupled receptor 161 isoform 1
NCBI Synonym Full Names:G protein-coupled receptor 161
NCBI Official Symbol:GPR161  
NCBI Official Synonym Symbols:RE2  
NCBI Protein Information:G-protein coupled receptor 161
UniProt Protein Name:G-protein coupled receptor 161
UniProt Synonym Protein Names:G-protein coupled receptor RE2
Protein Family:G-protein coupled receptor
UniProt Gene Name:GPR161  
UniProt Entry Name:
Antibodies
GPR161 Antibody (PACO09562)
Secondary Antibody
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