UniProt Protein Function: | GPR161: Orphan receptor. Plays a role in neurulation and lens development. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCRChromosomal Location of Human Ortholog: 1q24.2Cellular Component: cilium; recycling endosomeMolecular Function: G-protein coupled receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; positive regulation of cAMP biosynthetic process |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, this gene is a potential drug target for triple-negative breast cancer. [provided by RefSeq, Mar 2017] |
UniProt Code: | Q8N6U8 |
NCBI GenInfo Identifier: | 390190202 |
NCBI Gene ID: | 23432 |
NCBI Accession: | NP_001254538.1 |
UniProt Secondary Accession: | Q8N6U8,O75963, Q5TGK0, Q5TGK1, Q5TGK2, B3KV34, B7Z5D7 B7Z5E8, B7Z5Z6, F5GXD6 |
UniProt Related Accession: | Q8N6U8 |
Molecular Weight: | 30.4kD |
NCBI Full Name: | G-protein coupled receptor 161 isoform 1 |
NCBI Synonym Full Names: | G protein-coupled receptor 161 |
NCBI Official Symbol: | GPR161Â Â |
NCBI Official Synonym Symbols: | RE2Â Â |
NCBI Protein Information: | G-protein coupled receptor 161 |
UniProt Protein Name: | G-protein coupled receptor 161 |
UniProt Synonym Protein Names: | G-protein coupled receptor RE2 |
Protein Family: | G-protein coupled receptor |
UniProt Gene Name: | GPR161Â Â |
UniProt Entry Name: | |