The GPIHBP1 Polyclonal Antibody (CAB13240) is a valuable tool for studying GPIHBP1, a glycosylphosphatidylinositol-anchored protein involved in the binding and transport of lipoprotein lipase (LPL). This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the GPIHBP1 protein, researchers can investigate its role in lipid metabolism and potential implications in cardiovascular diseases like hypertriglyceridemia.GPIHBP1 plays a crucial role in facilitating the movement of LPL from the interstitial spaces to the capillary lumen, where it can hydrolyze triglycerides in circulating chylomicrons and very low-density lipoproteins.
Dysregulation of this process can lead to elevated plasma triglyceride levels, a risk factor for cardiovascular disorders like atherosclerosis. The GPIHBP1 Polyclonal Antibody offers researchers a reliable tool for exploring the mechanisms underlying lipid metabolism and identifying potential therapeutic targets for lipid-related conditions.
Product Name:
GPIHBP1 Rabbit Polyclonal Antibody
SKU:
CAB13240
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 50-151 of human GPIHBP1 (NP_835466.2).
This gene encodes a capillary endothelial cell protein that facilitates the lipolytic processing of triglyceride-rich lipoproteins. The encoded protein is a glycosylphosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly6) family. This protein plays a major role in transporting lipoprotein lipase (LPL) from the subendothelial spaces to the capillary lumen. Mutations in this gene are the cause of hyperlipoproteinemia, type 1D. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
338328
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GPIHBP1 Rabbit pAb (CAB13240) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
