glucose-6-phosphate isomerase Rabbit Monoclonal Antibody (CAB4401)
- SKU:
- CAB4401
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
Product Name: | glucose-6-phosphate isomerase Rabbit Monoclonal Antibody |
SKU: | CAB4401 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Glucose 6 phosphate isomerase (P06744). |
Sequence: | MAAL TRDP QFQK LQQW YREH RSEL NLRR LFDA NKDR FNHF SLTL NTNH GHIL VDYS KNLV TEDV MRML VDLA KSRG VEAA RERM FNGE KINY TEGR AVLH |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | AMF; NLK; PGI; PHI; GNPI; SA36; SA-36; [KD Validated] glucose-6-phosphate isomerase |
Positive Sample: | 293T,HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Secreted |
Calculated MW: | 63kDa |
Observed MW: | 60kDa |
This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 2821 |
Clone Number: | ARC0997 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |