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Gpi Antibody (PACO27149)

SKU:
PACO27149
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
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Description

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Gpi Antibody (PACO27149)

The GPI Antibody (PACO27149) is a highly specific and reliable tool for research involving Glycosylphosphatidylinositol (GPI)-linked proteins. This polyclonal antibody, raised in rabbits, is specifically designed for use in Western blot applications with human samples. GPI-linked proteins play essential roles in cell signaling, cell adhesion, and immune response regulation. The GPI Antibody binds specifically to GPI-linked proteins, enabling researchers to detect and analyze these critical molecules in a variety of cell types.

This makes it an ideal tool for studies in immunology, cell biology, and cancer research.Understanding the functions and mechanisms of GPI-linked proteins is crucial for advancing our knowledge of cellular processes and developing targeted therapies for diseases related to dysregulation of these proteins. The GPI Antibody provides researchers with a valuable tool for investigating the roles of GPI-linked proteins in various physiological and pathological conditions.

Antibody Name:Gpi Antibody (PACO27149)
Antibody SKU:PACO27149
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Mouse
Immunogen:Recombinant Mouse Glucose-6-phosphate isomerase protein (2-558AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.
Synonyms:Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI), Gpi, Gpi1
UniProt Protein Function:G6PI: belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. A dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. Functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.
UniProt Protein Details:

Protein type:Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; Apoptosis; Cytokine; Carbohydrate Metabolism - pentose phosphate pathway; EC 5.3.1.9; Isomerase

Cellular Component: cytoplasm; cytosol; membrane; myelin sheath; neuron projection; nucleoplasm; plasma membrane

Molecular Function:glucose-6-phosphate isomerase activity; intramolecular transferase activity; monosaccharide binding; protein binding; ubiquitin protein ligase binding

Biological Process: aldehyde catabolic process; carbohydrate metabolic process; erythrocyte homeostasis; glucose 6-phosphate metabolic process; glucose homeostasis; glycolysis; in utero embryonic development; mesoderm formation; methylglyoxal biosynthetic process; negative regulation of caspase activity; negative regulation of neuron apoptosis; response to morphine

NCBI Summary:This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phophsate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. [provided by RefSeq, Jan 2014]
UniProt Code:P06745
NCBI GenInfo Identifier:146345422
NCBI Gene ID:14751
NCBI Accession:P06745.4
UniProt Secondary Accession:P06745,O89062, Q3TEE7, Q3TW50, Q3UUX1, Q3UY84, Q3UZJ1 Q5RJI3, Q8C675, Q9JM07,
UniProt Related Accession:P06745
Molecular Weight:62,767 Da
NCBI Full Name:Glucose-6-phosphate isomerase
NCBI Synonym Full Names:glucose phosphate isomerase 1
NCBI Official Symbol:Gpi1  
NCBI Official Synonym Symbols:MF; NK; Amf; Gpi; Nlk; Org; Pgi; Phi; Gpi-1; Gpi1s; Gpi-1r; Gpi-1s; Gpi-1t; Gpi1-r; Gpi1-s; Gpi1-t; NK/GPI  
NCBI Protein Information:glucose-6-phosphate isomerase
UniProt Protein Name:Glucose-6-phosphate isomerase
UniProt Synonym Protein Names:Autocrine motility factor; AMF; Neuroleukin; NLK; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI
Protein Family:GPI-anchored protein
UniProt Gene Name:Gpi  
UniProt Entry Name:G6PI_MOUSE

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