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GPI Monoclonal Antibody [PAT22G2AT] (CPAB0217)

SKU:
CPAB0217
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a 
Clone:
PAT22G2AT
Applications:
ELISA
FC
€149
Frequently bought together:

Description

system_update_alt Datasheet

GPI Monoclonal Antibody [PAT22G2AT] (CPAB0217)

The GPI Antibody (CPAB0217) is a high-quality polyclonal antibody designed for research involving Glycosylphosphatidylinositol (GPI) anchoring of proteins to the cell membrane. The antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications, including Western blotting and immunohistochemistry.GPI anchoring is a crucial post-translational modification that plays a key role in the localization and function of proteins on the cell surface. The GPI Antibody (CPAB0217) specifically binds to GPI-anchored proteins, enabling researchers to detect and analyze these important molecules in different cell types and tissues.

This makes the antibody ideal for studies in cell biology, signal transduction, and membrane protein trafficking.Understanding the mechanisms and functions of GPI anchoring is essential for unraveling the complexities of cell signaling and communication. The GPI Antibody (CPAB0217) provides a valuable tool for investigating the roles of GPI-anchored proteins in various physiological and pathological processes, including cancer, infectious diseases, and neurodegenerative disorders. By targeting GPI-anchored proteins, researchers can gain insights into potential therapeutic targets for treating these conditions.

Product Name:GPI Antibody
Product Sku:CPAB0217
Size:5μg
Host Species:Mouse
Immunogen:Anti-human GPI mAb, clone PAT22G2AT, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human GPI protein 1-558 amino acids purified from Ecoli.
Clone:PAT22G2AT.
Reactivity:Human
Applications:ELISA, Flow Cytometry
Purification Method:GPI antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG2a 
Background:Glucose-6-phosphate isomerase (GPI) is a part of the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. GPI is a dimeric enzyme which catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. Mammalian GPI also functions as a tumor-secreted cytokine and an angiogenic factor (AMF) which stimulates endothelial cell motility. In addition, GPI is a neurotrophic factor (Neuroleukin) for spinal and sensory neurons. GPI performs in different capacities inside and outside the cell. In the cytoplasm, GPI is involved in glycolysis and gluconeogenesis, while outside the cell it acts as a neurotrophic factor for spinal and sensory neurons. Defects in the GPI gene cause the nonspherocytic hemolytic anemia and a severe enzyme deficiency can be linked to hydrops fetalis, immediate neonatal death and neurological impairment.
Synonyms:Glucose-6-phosphate isomerase, Phosphoglucose isomerase, Phosphohexose isomerase, Autocrine motility factor, Neuroleukin, Sperm antigen 36, GPI, PGI, PHI, AMF, NLK, SA-36, GNPI.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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