The GPC4 Polyclonal Antibody (CAB12805) is a valuable tool for researchers studying GPC4, a cell surface proteoglycan that plays key roles in development, cell signaling, and disease progression. This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting GPC4 in human samples, making it suitable for a variety of research applications, including immunohistochemistry and flow cytometry.GPC4 is known to interact with various growth factors and signaling molecules, influencing processes such as cell proliferation, migration, and differentiation. Dysregulation of GPC4 expression has been implicated in several diseases, including cancer, cardiovascular disorders, and developmental abnormalities.
By targeting GPC4, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify therapeutic targets for intervention.With its ability to specifically recognize GPC4, the CAB12805 antibody allows for accurate detection and analysis of GPC4 expression in different cell types and tissues, supporting investigations into the functional roles of this proteoglycan in health and disease. Its versatility and reliability make it an essential tool for researchers seeking to unravel the complexities of GPC4 biology and its implications for human health.
Product Name:
GPC4 Rabbit Polyclonal Antibody
SKU:
CAB12805
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 357-556 of human GPC4 (NP_001439.2).
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.
Purification Method:
Affinity purification
Gene ID:
2239
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GPC4 Rabbit pAb (CAB12805) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
