The GPBP1 Polyclonal Antibody (PACO09543) is a valuable tool for researchers studying GPBP1, a protein involved in various cellular processes, including DNA repair and cell cycle regulation. The antibody, produced in rabbits, exhibits high specificity and sensitivity towards GPBP1 in human samples, making it suitable for Western blotting applications. By targeting GPBP1, this antibody enables accurate detection and analysis of the protein in different cell types, making it an excellent choice for studies in molecular biology and cancer research.
GPBP1, also known as G-rich sequence binding protein 1, plays a crucial role in maintaining genomic stability and promoting cell survival under genotoxic stress conditions. Its involvement in DNA damage response pathways highlights its potential as a therapeutic target for cancer treatment and other diseases associated with DNA repair deficiencies. Investigating the function of GPBP1 is essential for uncovering its role in disease progression and developing novel treatments that exploit its functions for therapeutic purposes.
GC-rich promoter binding protein 1;GPBP1;DKFZp761C169;GPBP;MGC126339;VASCULIN ;
UniProt Protein Function:
GPBP1: a novel vascular protein differentially expressed in human atherogenesis. Can be found in the plasma, thus it may be a possible marker for atherosclerosis.Protein type: Transcription factorChromosomal Location of Human Ortholog: 5q11.2Cellular Component: intracellular membrane-bound organelle; cytoplasm; nucleolus; plasma membraneMolecular Function: DNA binding; transcription factor activityBiological Process: transcription, DNA-dependent; positive regulation of transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiquitously expressed. This protein is suggested to play a role in the development of atherosclerosis. Studies in mice suggest that it may also function as a GC-rich promoter-specific trans-activating transcription factor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
