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GOSR1 Antibody (PACO65153)

SKU:
PACO65153
Product Type:
Antibody
Reactivity:
Human, Mouse
Clonality:
Polyclonal
Target:
GOSR1
  • GOSR1 Antibody (PACO65153)
  • GOSR1 Antibody (PACO65153)
  • GOSR1 Antibody (PACO65153)
€299
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Description

Product Name: GOSR1 Antibody
SKU: PACO65153
Size: 50μl, 100μl
UniProt No: O95249
Target Names: GOSR1
Alternative Names: GOSR1; GS28; Golgi SNAP receptor complex member 1; 28 kDa Golgi SNARE protein; 28 kDa cis-Golgi SNARE p28; GOS-28
Species Reactivity: Human, Mouse
Immunogen: Recombinant Human Golgi SNAP receptor complex member 1 protein (1-115AA)
Immunogen Species: Homo sapiens (Human)
Clonality: Polyclonal
Purification Method: Antigen Affinity Purified
Conjugate: Non-conjugated
Form: Liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time: Basically, we can dispatch the products out in 7-10 working days after receiving your orders. Delivery time may differ depending on the purchasing method or location. Please consult your local distributors for specific delivery times.
Tested Applications: ELISA WB IHC
Recommended Dilution:
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
Function: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
Gene References into Functions:
  1. These results indicate that GS28 nuclear predominant expression could serve as a prognostic marker for colorectal cancer (CRC) and may help in identifying aggressive forms of CRC PMID: 28638266
  2. High nuclear expression of GS28 is associated with poor prognosis in early-stage cervical cancer patients. GS28 might be a novel prognostic marker and a potential therapeutic target in cervical cancer treatment. PMID: 27611086
  3. Golgi vesicles, presumably with COPI, serve to inhibit intra-Golgi transport by the extraction of GS27 and GS28 from the Golgi cisternae, which blocks the formation of inter-cisternal connections PMID: 23387339
  4. GS28 may potentiate cells to DNA-damage-induced apoptosis by inhibiting the ubiquitination and degradation of p53. PMID: 22397410
  5. ORP7 negatively regulates GS28 protein stability via sequestration of GATE-16, and may mediate the effect of 25-OH on GS28 and Golgi function. PMID: 21669198
  6. Apolipoprotein E, growth factor receptor-bound protein 2, Golgi SNAP receptor complex member 1, and glucosidase, beta, acid may play a neurodegenerative role in stress urinary incontinence development. PMID: 20700730
  7. Data suggest that GS15 exists in a distinct SNARE complex that contains syntaxin5, GS28, and Ykt6, and may be involved in both ER-to-Golgi and intra-Golgi transport. PMID: 12388752
Subcellular Location: Golgi apparatus membrane; Single-pass type IV membrane protein.
Protein Families: GOSR1 family
Database Links:

HGNC: 4430

OMIM: 604026

KEGG: hsa:9527

STRING: 9606.ENSP00000225724

UniGene: Hs.462680
Western Blotting(WB) - GOSR1 Antibody Western blot
All lanes: GOSR1 antibody at 16μg/ml + Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 29, 22 kDa
Observed band size: 29 kDa
Immunohistochemistry(IHC) 1- GOSR1 Antibody Immunohistochemistry of paraffin-embedded human colon cancer using PACO65153 at dilution of 1:100
Immunohistochemistry(IHC) 2- GOSR1 Antibody Immunohistochemistry of paraffin-embedded human placenta tissue using PACO65153 at dilution of 1:100.

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