GNPTAB Rabbit Polyclonal Antibody (CAB15895)
- SKU:
- CAB15895
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | GNPTAB Rabbit Polyclonal Antibody |
SKU: | CAB15895 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 42-350 of human GNPTAB (NP_077288.2). |
Sequence: | LEWS RDQY HVLF DSYR DNIA GKSF QNRL CLPM PIDV VYTW VNGT DLEL LKEL QQVR EQME EEQK AMRE ILGK NTTE PTKK SEKQ LECL LTHC IKVP MLVL DPAL PANI TLKD LPSL YPSF HSAS DIFN VAKP KNPS TNVS VVVF DSTK DVED AHSG LLKG NSRQ TVWR GYLT TDKE VPGL VLMQ DLAF LSGF PPTF KETN QLKT KLPE NLSS KVKL LQLY SEAS VALL KLNN PKDF QELN KQTK KNMT IDGK ELTI SPAY LLWD LSAI SQSK QDED ISAS RFED NEEL RYSL RSIE RHAP WVRN IFIV T |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | ICD; GNPTA; GNPTAB |
Positive Sample: | LO2,293T |
Conjugate: | Unconjugated |
Cellular Localization: | Golgi apparatus membrane, Single-pass type I membrane protein, Single-pass type II membrane protein. |
Calculated MW: | 144kDa |
Observed MW: | 144kDa |
This gene encodes two of three subunit types of the membrane-bound enzyme N-acetylglucosamine-1-phosphotransferase, a heterohexameric complex composed of two alpha, two beta, and two gamma subunits. The encoded protein is proteolytically cleaved at the Lys928-Asp929 bond to yield mature alpha and beta polypeptides while the gamma subunits are the product of a distinct gene (GeneID 84572). In the Golgi apparatus, the heterohexameric complex catalyzes the first step in the synthesis of mannose 6-phosphate recognition markers on certain oligosaccharides of newly synthesized lysosomal enzymes. These recognition markers are essential for appropriate trafficking of lysosomal enzymes. Mutations in this gene have been associated with both mucolipidosis II and mucolipidosis IIIA.
Purification Method: | Affinity purification |
Gene ID: | 79158 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |