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GNMT Monoclonal Antibody [PAT3F6AT] (CPAB0206)

SKU:
CPAB0206
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
PAT3F6AT
Applications:
WB
ELISA
FC
$179
Frequently bought together:

Description

system_update_alt Datasheet
Product Name:GNMT Antibody
Product Sku:CPAB0206
Size:5μg
Host Species:Mouse
Immunogen:Anti-human GNMT mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human GNMT amino acids 44-51 purified from Ecoli.
Clone:PAT3F6AT.
Reactivity:Human
Applications:Western Blot, ELISA, Flow Cytometry
Purification Method:GNMT antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG2a
Background:GNMT is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine with glycine to S-adenosyl-L-homocysteine and sarcosine. GNMT is located in the cytoplasm and acts as a homotetramer. Defects in the GNMT gene causes of GNMT deficiency (hypermethioninemia). GNMT affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine and is involved in the detoxification pathway in liver cells. GNMT expression is diminished in human hepatocellular carcinoma (HCC). GNMT catalyzes the methylation of glycine by using s- adenosylmethionine (adomet) to form n-methylglycine (sarcosine) with the concomitant production of s-adenosylhomocysteine (adohcy). GNMT plays an essential role in the regulation of tissue concentration of adomet and of metabolism of methionine.
Synonyms:Glycine N-methyltransferase, GNMT.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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