GNL3L Antibody (PACO40662)
- SKU:
- PACO40662
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
GNL3L Antibody (PACO40662)
The GNL3L Polyclonal Antibody (PACO40662) is a valuable tool for researchers studying the GNL3 like (GNL3L) protein, which plays a role in cell growth and proliferation. This antibody, produced in rabbits, is highly specific to human samples and is optimized for Western blot applications. By targeting the GNL3L protein, this antibody enables researchers to detect and analyze its expression in various cell types, making it ideal for studies in cancer biology and cell signaling.
GNL3L is a member of the GNL3 family, which is involved in ribosome biogenesis and cell cycle progression. Dysregulation of GNL3L has been linked to tumorigenesis and other diseases, making it a potential therapeutic target. By understanding the function of GNL3L, researchers can gain insights into the mechanisms underlying cancer development and potentially identify new targets for therapeutic intervention.
| Antibody Name: | GNL3L Antibody (PACO40662) |
| Antibody SKU: | PACO40662 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Guanine nucleotide-binding protein-like 3-like protein (1-582AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. |
| Synonyms: | Guanine nucleotide-binding protein-like 3-like protein, GNL3L |
| UniProt Protein Function: | GNL3L: Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. Belongs to the MMR1/HSR1 GTP-binding protein family.Protein type: NucleolusChromosomal Location of Human Ortholog: Xp11.22Cellular Component: cytoplasm; membrane; mitochondrion; nucleolus; nucleus; telomerase holoenzyme complexMolecular Function: GTPase activity; protein bindingBiological Process: negative regulation of protein binding; negative regulation of protein sumoylation; negative regulation of protein ubiquitination; negative regulation of telomere maintenance via telomerase; regulation of protein stability; ribosome biogenesis and assembly |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010] |
| UniProt Code: | Q9NVN8 |
| NCBI GenInfo Identifier: | 74752999 |
| NCBI Gene ID: | 54552 |
| NCBI Accession: | Q9NVN8.1 |
| UniProt Secondary Accession: | Q9NVN8 |
| UniProt Related Accession: | Q9NVN8 |
| Molecular Weight: | 65,573 Da |
| NCBI Full Name: | Guanine nucleotide-binding protein-like 3-like protein |
| NCBI Synonym Full Names: | G protein nucleolar 3 like |
| NCBI Official Symbol: | GNL3LÂ Â |
| NCBI Official Synonym Symbols: | GNL3BÂ Â |
| NCBI Protein Information: | guanine nucleotide-binding protein-like 3-like protein |
| UniProt Protein Name: | Guanine nucleotide-binding protein-like 3-like protein |
| UniProt Synonym Protein Names: | |
| Protein Family: | Guanine nucleotide-binding protein-like 3-like protein |
| UniProt Gene Name: | GNL3LÂ Â |
| UniProt Entry Name: | GNL3L_HUMAN |
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