The GNG5 Antibody (PAC003908) is a high-quality, polyclonal antibody specifically designed for research involving GNG5, a protein essential for G protein signaling. Raised in rabbits, this antibody is highly reactive with human samples and is validated for use in various applications, including Western blotting. By binding to the GNG5 protein, this antibody enables precise detection and analysis in a wide range of cell types, making it an ideal tool for studies in molecular biology and signal transduction pathways.
GNG5 is a key player in G protein-coupled receptor signaling, a fundamental process in cell signaling and communication. By targeting GNG5, researchers can gain insight into the regulation of cellular pathways and potentially identify new therapeutic targets for diseases such as cardiovascular disorders, neurological conditions, and cancer. Understanding the function of GNG5 is crucial for advancing our knowledge of signal transduction mechanisms and developing novel treatment strategies.
Antibody Name:
GNG5 Antibody
Antibody SKU:
PACO03908
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
IF:1:200-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the N-terminal region of human Ggamma 5.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
GNG5; GNGT5; Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
UniProt Protein Function:
G-gamma 5: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Belongs to the G protein gamma family.Protein type: G protein, heterotrimeric; G protein, heterotrimeric gamma; G protein; MitochondrialChromosomal Location of Human Ortholog: 1p22Cellular Component: membrane; plasma membraneMolecular Function: PDZ domain binding; protein binding
UniProt Protein Details:
NCBI Summary:
G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]
