GNE Rabbit Polyclonal Antibody (CAB8570)
- SKU:
- CAB8570
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | GNE Rabbit Polyclonal Antibody |
SKU: | CAB8570 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human GNE (NP_001121699.1). |
Sequence: | METY GYLQ RESC FQGP HELY FKNL SKRN KQIM EKNG NNRK LRVC VATC NRAD YSKL APIM FGIK TEPE FFEL DVVV LGSH LIDD YGNT YRMI EQDD FDIN TRLH TIVR GEDE AAMV ESVG LALV KLPD VLNR LKPD IMIV HGDR FDAL AL |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:100 |
Synonyms: | NM; DMRV; IBM2; Uae1; GLCNE; GNE |
Positive Sample: | LO2,Jurkat,HeLa,mouse liver,rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 79kDa |
Observed MW: | 79kDa |
The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 10020 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |