GNB3 Rabbit Polyclonal Antibody (CAB1387)
- SKU:
- CAB1387
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | GNB3 Rabbit Polyclonal Antibody |
SKU: | CAB1387 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-340 of human GNB3 (NP_002066.1). |
Sequence: | MGEM EQLR QEAE QLKK QIAD ARKA CADV TLAE LVSG LEVV GRVQ MRTR RTLR GHLA KIYA MHWA TDSK LLVS ASQD GKLI VWDS YTTN KVHA IPLR SSWV MTCA YAPS GNFV ACGG LDNM CSIY NLKS REGN VKVS RELS AHTG YLSC CRFL DDNN IVTS SGDT TCAL WDIE TGQQ KTVF VGHT GDCM SLAV SPDF NLFI SGAC DASA KLWD VREG TCRQ TFTG HESD INAI CFFP NGEA ICTG SDDA SCRL FDLR ADQE LICF SHES IICG ITSV AFSL SGRL LFAG YDDF NCNV WDSM KSER VGIL SGHD NRVS CLGV TADG MAVA TGSW DSFL KIWN |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | HG2D; CSNB1H; GNB3 |
Positive Sample: | HT-29,SKOV3,SH-SY5Y,Mouse brain,Mouse heart,Mouse eye,Rat brain,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol, dendrite, extracellular exosome, plasma membrane |
Calculated MW: | 37kDa |
Observed MW: | 35kDa |
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Purification Method: | Affinity purification |
Gene ID: | 2784 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |