The GNB3 Polyclonal Antibody (CAB1387) is a valuable tool for researchers studying GNB3, a key protein involved in signal transduction and cellular processes. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the GNB3 protein, this antibody allows for detection and analysis in a variety of cell types, making it an essential component for studies in molecular biology and drug development.GNB3, a member of the G protein family, plays a crucial role in transmitting signals from cell surface receptors to intracellular pathways, influencing various cellular functions such as growth, differentiation, and apoptosis.
Dysregulation of GNB3 has been associated with a range of diseases, including cardiovascular disorders, cancer, and neurological conditions. Research into the functions and interactions of GNB3 is vital for understanding these disease processes and developing targeted therapies to address them.Overall, the GNB3 Polyclonal Antibody (CAB1387) provides researchers with a reliable tool for investigating the functions and mechanisms of GNB3 in a variety of biological contexts, paving the way for new insights and potential therapeutic interventions.
Product Name:
GNB3 Rabbit Polyclonal Antibody
SKU:
CAB1387
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-340 of human GNB3 (NP_002066.1).
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Purification Method:
Affinity purification
Gene ID:
2784
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GNB3 antibody (CAB1387) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
