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GNAS Antibody (PACO13538)

SKU:
PACO13538
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
Frequently bought together:

Description

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GNAS Antibody (PACO13538)

The GNAS Polyclonal Antibody (PAC013538) is a valuable tool designed for research involving the G alpha subunit (GNAS), a critical regulator of cellular signaling pathways. This antibody is produced in rabbits and is highly specific to human samples, making it ideal for Western blot applications. By binding to GNAS, the antibody enables researchers to detect and analyze the protein in various cell types, providing valuable insights into signal transduction mechanisms in physiological and pathological conditions.GNAS plays a pivotal role in intracellular signaling cascades that regulate processes such as cell growth, differentiation, and hormone secretion.

Dysregulation of GNAS signaling has been implicated in a variety of diseases, including endocrine disorders, metabolic syndromes, and certain types of cancer. Understanding the complex functions of GNAS is essential for developing targeted therapies that can modulate its activity and potentially treat these conditions effectively.Overall, the GNAS Polyclonal Antibody is a reliable tool for scientists interested in investigating the role of GNAS in cellular signaling pathways and disease pathogenesis. Its high specificity and sensitivity make it a valuable asset for research in fields such as endocrinology, oncology, and molecular biology.

Antibody Name:GNAS Antibody (PACO13538)
Antibody SKU:PACO13538
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human NESP55,GNAS
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:GNAS complex locus;GNAS;AHO;C20orf45;GNAS1;GPSA;GSA;GSP;MGC33735;NESP;PHP1A;PHP1B;POH;dJ309F20.1.1;dJ806M20.3.3 ;
UniProt Protein Function:G-alpha(s) iso7: a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Agonist binding to Gq-coupled receptors may block Akt activation via the release of active G-alpha(q) subunits that inhibit phosphatidylinositol 3-kinase. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
UniProt Protein Details:

Protein type:Oncoprotein; Membrane protein, peripheral; G protein; G protein, heterotrimeric; Vesicle; G protein, heterotrimeric alpha G(s)

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: cytoplasm; cytosol; dendrite; extracellular region; heterotrimeric G-protein complex; intrinsic to membrane; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; ruffle; trans-Golgi network membrane; transport vesicle

Molecular Function:beta-2 adrenergic receptor binding; corticotropin-releasing hormone receptor 1 binding; D1 dopamine receptor binding; G-protein beta/gamma-subunit binding; GTP binding; GTPase activity; insulin-like growth factor receptor binding; ionotropic glutamate receptor binding; metal ion binding; mu-type opioid receptor binding; protein binding; signal transducer activity

Biological Process: adenylate cyclase activation; cartilage development; cognition; developmental growth; DNA methylation; dopamine receptor, adenylate cyclase activating pathway; embryonic cranial skeleton morphogenesis; embryonic hindlimb morphogenesis; endochondral ossification; energy reserve metabolic process; female pregnancy; G-protein signaling, adenylate cyclase activating pathway; intracellular transport; metabolic process; multicellular organism growth; negative regulation of multicellular organism growth; positive regulation of cAMP biosynthetic process; positive regulation of GTPase activity; positive regulation of osteoblast differentiation; positive regulation of osteoclast differentiation; post-embryonic body morphogenesis; protein secretion; regulation of insulin secretion; regulation of signal transduction; renal water homeostasis; response to drug; sensory perception of chemical stimulus; sensory perception of smell; tissue homeostasis

Disease: Acth-independent Macronodular Adrenal Hyperplasia; Mccune-albright Syndrome; Osseous Heteroplasia, Progressive; Pituitary Adenoma, Acth-secreting; Pituitary Adenoma, Growth Hormone-secreting; Pseudohypoparathyroidism, Type Ia; Pseudohypoparathyroidism, Type Ib; Pseudopseudohypoparathyroidism

NCBI Summary:This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]
UniProt Code:O95467
NCBI GenInfo Identifier:74706023
NCBI Gene ID:2778
NCBI Accession:O95467.1
UniProt Secondary Accession:O95467,O95417, B2RB88, E1P5G2,
UniProt Related Accession:P63092,O95467,P84996,Q5JWF2
Molecular Weight:111,025 Da
NCBI Full Name:Neuroendocrine secretory protein 55
NCBI Synonym Full Names:GNAS complex locus
NCBI Official Symbol:GNAS  
NCBI Official Synonym Symbols:AHO; GSA; GSP; POH; GPSA; NESP; SCG6; SgVI; GNAS1; C20orf45  
NCBI Protein Information:protein ALEX; protein GNAS; protein SCG6 (secretogranin VI)
UniProt Protein Name:Neuroendocrine secretory protein 55
UniProt Gene Name:GNAS  
UniProt Entry Name:GNAS3_HUMAN

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