Gnao1 Antibody (PACO27069)
- SKU:
- PACO27069
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Gnao1 Antibody (PACO27069)
The GNAO1 Polyclonal Antibody (PAC027069) is a valuable tool for researchers studying GNAO1, a guanine nucleotide-binding protein involved in signal transduction pathways. This antibody, produced in rabbits, is highly specific for human samples and is validated for use in Western blot applications. By binding to the GNAO1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential tool for investigations in neuroscience and neurology research.GNAO1, also known as G protein subunit alpha o1, plays a crucial role in neuronal function and communication by regulating neurotransmitter release and synaptic transmission.
Mutations in GNAO1 have been associated with a range of neurological disorders, including movement disorders, epilepsy, and developmental delay. Understanding the function of GNAO1 is essential for unraveling the mechanisms underlying these conditions and developing targeted treatments for patients affected by GNAO1-related disorders.
| Antibody Name: | Gnao1 Antibody (PACO27069) |
| Antibody SKU: | PACO27069 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Mouse, Rat |
| Immunogen: | Recombinant Mouse Guanine nucleotide-binding protein G(o) subunit α protein (2-354AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot Positive WB detected in: Rat brain tissue, Mouse brain tissue All lanes: Gnao1 antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 41 kDa Observed band size: 41 kDa . |
| Background: | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Stimulated by RGS14. The G(o) protein function is not clear. |
| Synonyms: | Guanine nucleotide-binding protein G(o) subunit alpha, Gnao1, Gna0 Gnao |
| UniProt Protein Function: | G-alpha(o): Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. Interacts with RGS14. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Belongs to the G-alpha family. G(i/o/t/z) subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z)); G proteinCellular Component: dendrite; heterotrimeric G-protein complex; membrane; myelin sheath; neuron projection; plasma membrane; protein complexMolecular Function: corticotropin-releasing hormone receptor 1 binding; G-protein beta/gamma-subunit binding; GTP binding; GTPase activating protein binding; GTPase activity; guanyl nucleotide binding; metabotropic serotonin receptor binding; metal ion binding; mu-type opioid receptor binding; nucleotide binding; protein binding; protein complex binding; signal transducer activityBiological Process: aging; cellular process; dopamine receptor signaling pathway; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; locomotory behavior; negative regulation of calcium ion transport; positive regulation of GTPase activity; regulation of heart contraction; response to organic nitrogen; signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P18872 |
| NCBI GenInfo Identifier: | 164607137 |
| NCBI Gene ID: | 14681 |
| NCBI Accession: | NP_001106855.1 |
| UniProt Secondary Accession: | P18872,P18873 |
| UniProt Related Accession: | P18872 |
| Molecular Weight: | 40,036 Da |
| NCBI Full Name: | guanine nucleotide-binding protein G(o) subunit alpha isoform B |
| NCBI Synonym Full Names: | guanine nucleotide binding protein, alpha O |
| NCBI Official Symbol: | Gnao1Â Â |
| NCBI Official Synonym Symbols: | Gnao; alphaO; Galphao; AW050213Â Â |
| NCBI Protein Information: | guanine nucleotide-binding protein G(o) subunit alpha |
| UniProt Protein Name: | Guanine nucleotide-binding protein G(o) subunit alpha |
| UniProt Synonym Protein Names: | |
| Protein Family: | Guanine nucleotide-binding protein |
| UniProt Gene Name: | Gnao1Â Â |
| UniProt Entry Name: | GNAO_MOUSE |
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