The GMPS Polyclonal Antibody (CAB6606) is a vital tool for research into guanine monophosphate synthase (GMPS), a key enzyme involved in nucleotide biosynthesis and cell growth regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the GMPS protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for studies in molecular biology, cancer research, and drug development.
GMPS plays a crucial role in maintaining cellular health by catalyzing the formation of guanine nucleotides, essential building blocks for DNA and RNA synthesis. Dysregulation of GMPS activity has been linked to various diseases, including cancer and genetic disorders, highlighting its potential as a therapeutic target. Investigating the function of GMPS with the help of this polyclonal antibody is key to unlocking new insights into cellular metabolism and disease mechanisms, paving the way for novel treatment strategies.
Product Name:
GMPS Rabbit Polyclonal Antibody
SKU:
CAB6606
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 394-693 of human GMPS (NP_003866.1).
In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.
Purification Method:
Affinity purification
Gene ID:
8833
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using GMPS Rabbit pAb (CAB6606) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
