UniProt Protein Function: | GMPR2: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation. Belongs to the IMPDH/GMPR family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 1.7.1.7; Nucleotide Metabolism - purine; OxidoreductaseChromosomal Location of Human Ortholog: 14q12Cellular Component: cytosolMolecular Function: GMP reductase activity; metal ion bindingBiological Process: nucleobase, nucleoside and nucleotide metabolic process; purine salvage; GMP metabolic process; purine base metabolic process |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | Q9P2T1 |
NCBI GenInfo Identifier: | 50541952 |
NCBI Gene ID: | 51292 |
NCBI Accession: | NP_001002000.1 |
UniProt Secondary Accession: | Q9P2T1,Q567T0, Q6IAJ8, Q86T14, D3DS66 |
UniProt Related Accession: | Q9P2T1 |
Molecular Weight: | 34,597 Da |
NCBI Full Name: | GMP reductase 2 isoform 2 |
NCBI Synonym Full Names: | guanosine monophosphate reductase 2 |
NCBI Official Symbol: | GMPR2Â Â |
NCBI Official Synonym Symbols: | |
NCBI Protein Information: | GMP reductase 2; guanosine 5'-monophosphate oxidoreductase 2; guanosine monophosphate reductase isolog |
UniProt Protein Name: | GMP reductase 2 |
UniProt Synonym Protein Names: | Guanosine 5'-monophosphate oxidoreductase 2; Guanosine monophosphate reductase 2 |
Protein Family: | GMP reductase |
UniProt Gene Name: | GMPR2Â Â |
UniProt Entry Name: | GMPR2_HUMAN |