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GMPR2 Antibody (PACO41226)

SKU:
PACO41226
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€359

Description

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GMPR2 Antibody (PACO41226)

The GMPR2 Polyclonal Antibody (PAC041226) is a valuable tool for researchers studying GMPR2, a key enzyme involved in guanosine metabolism. This antibody is produced in rabbits and has high reactivity with human samples, making it ideal for Western blot applications. By targeting the GMPR2 protein, this antibody allows for the detection and analysis of GMPR2 levels in various cell types.GMPR2 plays a crucial role in maintaining guanosine nucleotide balance, which is essential for cellular functions such as DNA and RNA synthesis.

Dysregulation of GMPR2 has been implicated in diseases such as cancer and neurological disorders, making it a promising target for further research. By studying GMPR2 using this antibody, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially develop targeted therapies in the future.

Antibody Name:GMPR2 Antibody (PACO41226)
Antibody SKU:PACO41226
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Human
Immunogen:Recombinant Human GMP reductase 2 protein (1-366AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation.
Synonyms:GMP reductase 2 (GMPR 2) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2), GMPR2
UniProt Protein Function:GMPR2: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation. Belongs to the IMPDH/GMPR family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 1.7.1.7; Nucleotide Metabolism - purine; OxidoreductaseChromosomal Location of Human Ortholog: 14q12Cellular Component: cytosolMolecular Function: GMP reductase activity; metal ion bindingBiological Process: nucleobase, nucleoside and nucleotide metabolic process; purine salvage; GMP metabolic process; purine base metabolic process
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9P2T1
NCBI GenInfo Identifier:50541952
NCBI Gene ID:51292
NCBI Accession:NP_001002000.1
UniProt Secondary Accession:Q9P2T1,Q567T0, Q6IAJ8, Q86T14, D3DS66
UniProt Related Accession:Q9P2T1
Molecular Weight:34,597 Da
NCBI Full Name:GMP reductase 2 isoform 2
NCBI Synonym Full Names:guanosine monophosphate reductase 2
NCBI Official Symbol:GMPR2  
NCBI Official Synonym Symbols:
NCBI Protein Information:GMP reductase 2; guanosine 5'-monophosphate oxidoreductase 2; guanosine monophosphate reductase isolog
UniProt Protein Name:GMP reductase 2
UniProt Synonym Protein Names:Guanosine 5'-monophosphate oxidoreductase 2; Guanosine monophosphate reductase 2
Protein Family:GMP reductase
UniProt Gene Name:GMPR2  
UniProt Entry Name:GMPR2_HUMAN

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