The Geminin Polyclonal Antibody (CAB5316) is a valuable tool for researchers studying the Geminin protein, a key regulator of cell cycle progression and DNA replication. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blotting applications. It specifically binds to the Geminin protein, allowing for accurate detection and analysis in various cell types.Geminin is known for its important role in preventing re-replication of DNA during the cell cycle, making it a critical protein in maintaining genomic stability.
Dysregulation of Geminin has been linked to various diseases, including cancer, where aberrant Geminin expression can lead to uncontrolled cell division.By utilizing the Geminin Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of this protein, leading to a better understanding of its implications in cancer development and other diseases. This antibody is a valuable tool for studies in cell biology, oncology, and other fields where the cell cycle is of interest.
Product Name:
GMNN Rabbit Polyclonal Antibody
SKU:
CAB5316
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-209 of human GMNN (NP_056979.1).
This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.
Purification Method:
Affinity purification
Gene ID:
51053
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using GMNN Rabbit pAb (CAB5316) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
