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GMNN Monoclonal Antibody [P2H7AT] (CPAB0515)

SKU:
CPAB0515
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG1
Clone:
P2H7AT
Applications:
WB
ELISA
$179
Frequently bought together:

Description

system_update_alt Datasheet

GMNN Monoclonal Antibody [P2H7AT] (CPAB0515)

The GMNN Monoclonal Antibody (CPAB0515) from AssayGenie is a valuable tool for researchers studying the GMNN protein, which is known to play a key role in cell cycle regulation and DNA replication. This antibody, produced in a monoclonal format, shows high specificity and sensitivity in detecting GMNN in various biological samples.GMNN, also known as geminin, is a crucial protein that helps maintain genomic stability by preventing re-replication of DNA during cell division. Dysregulation of GMNN has been implicated in various human diseases, including cancer.

By using the CPAB0515 antibody, researchers can effectively study the expression and localization of GMNN in different cell types and tissues.This antibody has been validated for use in applications such as immunofluorescence, immunohistochemistry, and Western blotting, providing researchers with versatile options for their experimental needs. By utilizing the GMNN Monoclonal Antibody from AssayGenie, scientists can further unravel the complex mechanisms underlying cell cycle control and potentially uncover new therapeutic targets for disease intervention.

Product Name:GMNN Antibody
Product Sku:CPAB0515
Size:5μg
Host Species:Mouse
Immunogen:Anti-human Geminin mAb is derived from hybridization of mouse SP2/ myeloma cells with spleen cells from BALB/c mice immunized with recombinant human Geminin amino acids 1-29 purified from Ecoli.
Clone:P2H7AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA
Purification Method:Geminin antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG1
Background:Geminin is a 25 kDa nuclear protein, which inhibits DNA replication and is degraded during the mitotic phase of the cell cycle. Geminin controls replication by binding to the licensing factor Cdt1, and is involved in neural differentiation. In addition, Geminin directly interacts with Six3 and Hox homeodomain proteins during embryogenesis and inhibits their functions. Geminin can also promote DNA replication. Geminin has 2 roles in 2 different stages of the cell cycle: Geminin is a negative regulator of DNA replication during the €œS phase€ of the cell cycle. Inhibition of Geminin during the €œS phase€ (by RNAi) results in an additional round of replication of portions of the genome. During the €œM phase€ of the cell cycle (mitosis) Geminin stabilizes the replication factor Cdt1 promoting DNA replication during the next cell cycle. Moreover, inhibition of Geminin during mitosis (by RNAi) causes destabilization of Cdt1 protein and impairment of DNA replication during the next cell cycle. G
Synonyms:GMNN, Geminin, DNA Replication Inhibitor, Gem, RP3-369A17.3.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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