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GMFB Monoclonal Antibody [PAT44D8AT] (CPAB0083)

SKU:
CPAB0083
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
PAT44D8AT
Applications:
WB
ELISA
€149
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Description

system_update_alt Datasheet

GMFB Monoclonal Antibody [PAT44D8AT] (CPAB0083)

The GMFB Polyclonal Antibody (CPAB0083) is a valuable tool for researchers studying the GMFB protein, which is involved in various cellular processes and signaling pathways. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, enabling precise detection and analysis.GMFB, also known as glia maturation factor beta, plays a key role in neuronal development, synaptic plasticity, and cell survival. Its dysregulation has been linked to neurodegenerative diseases, making it a promising therapeutic target in neuroscience research.

The GMFB antibody is validated for use in Western blot applications, providing reliable results for studies investigating the function and regulation of GMFB in normal and diseased states.By utilizing the GMFB Polyclonal Antibody, researchers can gain deeper insights into the molecular mechanisms underlying neuronal function and dysfunction, paving the way for the development of novel therapeutic strategies for neurodegenerative disorders. This antibody is a valuable asset for studies exploring the intricate workings of GMFB in both health and disease.

Product Name:GMFB Antibody
Product Sku:CPAB0083
Size:5μg
Host Species:Mouse
Immunogen:Anti-human GMFB mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human GMFB amino acids 1-142 purified from Ecoli.
Clone:PAT44D8AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:GMFB antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG2a
Background:Glia Maturation Factor-Beta (GMF-Beta) is a 17 kDa protein nerve gorwth factor identified as a growth and differentiation factor in the vertebrate brain. Glia Maturation Factor-Beta stimulates differentiation of normal neurons as well as glial cells. GMFB inhibits the proliferation of the N-18 neuroblastoma line and the C6 glioma line while promoting their phenotypic expression. GMF-beta inhances the phenotypic expression of glia & neurons thus inhibits the proliferation of their respective tumors when added to cell culture. Although astrocytes produce GMF-b and stores it inside the cells, they donÂ’t secrete the GMF-B into the cultured medium. Cell- surface GMFb acts on the target cells at close range when cells are in direct contact. GMF-Beta is produced by thymic epithelial cells and plays an important role in T cell development in favor of CD4+ T cells. GMF-Beta is a brain-specific protein which belongs to the actin-binding proteins (ADF) family. GMF-beta appears to play a role in the differentiation, maintenance, and regeneration of the nervous system. It also supports the progression of certain auto-immune diseases, possibly through its ability to induce the production and secretion of various pro-inflammatory cytokines.
Synonyms:Glia maturation factor beta, GMFB, GMF-B, GMF-beta, GMF.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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