The GMEB2 Polyclonal Antibody (PAC009499) is a valuable tool for researchers studying GMEB2, a transcriptional regulator involved in gene expression and DNA-binding processes. This antibody, produced in rabbits, exhibits high specificity and sensitivity for GMEB2 in human samples, making it ideal for use in Western blot applications.GMEB2 is known to play a role in various cellular processes, including cell proliferation, differentiation, and apoptosis, making it a key player in cancer research and developmental biology studies. By targeting GMEB2, researchers can gain insight into its function and mechanism of action, paving the way for potential therapeutic interventions in diseases related to its dysregulation.
With its ability to detect GMEB2 in different cell types, the GMEB2 Polyclonal Antibody is a reliable tool for investigating the role of this transcriptional regulator in various biological pathways. Its versatility and high performance make it a valuable asset for researchers looking to advance their understanding of gene regulation and its implications in health and disease.
glucocorticoid modulatory element binding protein 2;GMEB2;KIAA1269;P79PIF;PIF79 ;
UniProt Protein Function:
GMEB2: Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.Protein type: Nuclear receptor co-regulatorChromosomal Location of Human Ortholog: 20q13.33Cellular Component: nucleoplasm; cytoplasm; nucleusMolecular Function: DNA binding; metal ion binding; transcription coactivator activityBiological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
