The GMEB1 Polyclonal Antibody (PAC042702) is a valuable tool for researchers studying GMEB1, a transcription factor known for its role in gene expression regulation and cell signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the GMEB1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it a versatile tool for studies in molecular biology and cancer research.GMEB1, also referred to as Glucocorticoid Modulatory Element Binding Protein 1, is a key player in transcriptional regulation processes that influence cell growth, differentiation, and survival.
Its involvement in various cellular functions makes it a promising target for investigating diseases such as cancer, neurodegenerative disorders, and metabolic syndromes. Understanding the mechanisms by which GMEB1 operates is essential for developing innovative therapeutic approaches that target gene expression and signaling cascades involved in disease progression.
Antibody Name:
GMEB1 Antibody (PACO42702)
Antibody SKU:
PACO42702
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human Glucocorticoid modulatory element-binding protein 1 protein (2-245AA)
Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.
Synonyms:
Glucocorticoid modulatory element-binding protein 1 (GMEB-1) (DNA-binding protein p96PIF) (Parvovirus initiation factor p96) (PIF p96), GMEB1
UniProt Protein Function:
GMEB1: Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Nuclear receptor co-regulatorChromosomal Location of Human Ortholog: 1p35.3Cellular Component: nucleoplasm; nucleusBiological Process: regulation of transcription from RNA polymerase II promoter
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Three alternative spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Feb 2016]
