The GM130 Polyclonal Antibody is a valuable tool for researchers studying the Golgi matrix protein 130 (GM130), a key regulator of Golgi structure and function. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the GM130 protein, this antibody enables detection and analysis in a variety of cell types, making it an essential component for research in cell biology and molecular biology.
GM130 is essential for maintaining the structure and function of the Golgi apparatus, a crucial organelle involved in protein processing and secretion. Dysregulation of GM130 has been implicated in various diseases, including neurodegenerative disorders and cancer. Studying the role of GM130 using this antibody can provide valuable insights into Golgi function and its impact on cellular processes, offering potential avenues for therapeutic development in disease contexts.
Product Name:
GM130 Polyclonal Antibody
SKU:
CAB24834
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 903-1002 of human GM130(NP_004477.5).
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined.
Purification Method:
Affinity purification
Gene ID:
2801
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells using GM130 Rabbit pAb(CAB24834) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time:0.5s.
